بررسی نقش محافظتی سلنیوم در جلوگیری از آسیب بافتی ناشی از دیازینون در موش های صحرایی
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Background and purpose: Diazinon (DZN) is a commonly used organophosphorous (OP) pesticide. It is synthetic chemical substance with broad spectrum insecticide activity [3].Toxic effects of diazinon are due to the inhibition of acetyl cholinesterase activity, an enzyme needed for proper nervous system function. It has been widely used throughout the world with applications in agriculture and horticulture for controlling insects [4,5]. The Se is an essential dietary trace element which plays an important role in a number of biological processes [18] consists of antioxidant and anti mutagenic properties Materials and methods: In the experiment, a total of 45 rats (200-250 gr) were used. The rats were randomly divided into 9 groups with five animals in each group. Animals were concurrently administered intraperitoneally with DZN in proper solvent (20 mg/kg body weight (b.w.)) and Se at three different doses (0.5, 1, and 2 mg/kg b.w.) for 30 consecutive days.After necropsy, liver and kidneys of all animals were isolated and fixed in 10% buffered formalin. Using examples of common practices pathology tissue sections, 5 microns thick sections by microtome and prepared for staining with hematoxylin - eosin were prepared. Results: In the liver of groups that diazinon had received, focal hepatic necrosis was created. Exposure also causes dilation of sinusoids in the liver parenchyma.Selenium in Dose of 0.5mg / kg asthecontrolgroup, although high dose 2mg / kg causesfibrosisandfocalnecrosis, venous congestion and spasticitytic. Ingroups with diazinon received Selenium 0.5 mg / kg lead toinflammatory cellinfiltrationin the portaltract and centralveindilatation.Together with theselenium 2 mg/kgdiazinoncausednecrosisand hepaticnecrosis inzone 3andspasticitytic.However,inthis study,diazinonwasinduced inflammation butnosignificantchangeinkidney of rat’s .necrosisanddestruction ofepithelial cellswere notobserved Conclusion: Thisstudy showed thatdiazinonhas theability to causeliver and kidneydamage, although the damage is less in kidney in comparison with liver damage.It was alsoobservedthatselenium in dose of 0.5 mg / kg is able toreducethedamage however the damage increased when the dose was increasing. It seems , selenium has a harmful role in increased doses, and it result to necrosis and fibrosis
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اثر بربرین در تنظیم آستروسیتهای Gfap+ ناحیه هیپوکمپ موشهای صحرایی دیابتی شده با استرپتوزوتوسین
Background: Diabetes mellitus increases the risk of central nervous system (CNS) disorders such as stroke, seizures, dementia, and cognitive impairment. Berberine, a natural isoquinolne alkaloid, is reported to exhibit beneficial effect in various neurodegenerative and neuropsychiatric disorders. Moreover astrocytes are proving critical for normal CNS function, and alterations in their activity...
full textاثر بربرین در تنظیم آستروسیتهای Gfap+ ناحیه هیپوکمپ موشهای صحرایی دیابتی شده با استرپتوزوتوسین
Background: Diabetes mellitus increases the risk of central nervous system (CNS) disorders such as stroke, seizures, dementia, and cognitive impairment. Berberine, a natural isoquinolne alkaloid, is reported to exhibit beneficial effect in various neurodegenerative and neuropsychiatric disorders. Moreover astrocytes are proving critical for normal CNS function, and alterations in their activity...
full textبررسی نقش محافظتی سلنیوم در جلوگیری از سمیت سرب در غده بزاقی تحت فکی موش صحرایی
مطالعات حیوانی نشان داده است که سلنیوم تا اندازه ای می تواند اثرات سمی سرب مانند سمیت کلیوی و سمیت عصبی را کاهش دهد ولی هیچگونه مطالعه ای در باره امکان تداخل میان سرب و سلنیوم در عملکرد غدد بزاقی انجام نشده است . این مطالعه طراحی شد تا اثرات محافظتی احتمالی سلنیوم بر اثرات ناشی از سرب در عملکرد غده بزاقی تحت فکی موش صحرایی را بررسی کند.
15 صفحه اولبررسی نقش محافظتی داروی گیاهی آیبروگست (STW5) در جلوگیری از آسیب هیستوپاتولوژیکی بافت کبد ناشی از التهاب حاد در موش صحرایی
زمینه و هدف: آیبروگست با نام تجاری STW5 یک داروی شناختهشده گیاهی است که ترکیبات ثابتی از عصاره هیدرواتانولی 9 گیاه داروی مختلف را دارا میباشد. این مطالعه با هدف بررسی اثرات محافظتی این دارو در دوزهای مختلف بر روی آسیب هیستوپاتولوژیکی بافت کبد در رتهای مبتلا به سپسیس در مدل تجربی CLP انجام شد. روش بررسی: در این مطالعه تجربی، 36 سر رت به 6 گروه (6 سر در هرگروه) تقسیم شدند: 1- گروه کنترل (SOP)؛...
full textبررسی اثرات سم دیازینون بر سطح گلوتاتیون کبد در موش صحرایی و نقش محافظتی سلنیوم و ال-کارنیتین بر آن
Background and purpose: Widespread use of pesticides in public health and agriculture has caused environmental pollution and increased risk of acute human poisonings. Diazinon is one of the most prevalent organophosphate pesticide (OPCs) in the world. Several studies suggest that organophosphate compounds cause oxidative stress and lipid peroxidation. Materials and methods: This study was perf...
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Journal title
volume 22 issue 2
pages 92- 98
publication date 2013-03
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